The building that houses the Museum is the house that the musician had built with the intention of making it his residence upon his return to his hometown. The old rural building, purchased by Spontini in 1842 from the Valchera family, was renovated in the neoclassical style between 1843 and 1846 by the architect Ciriaco Santini, from Jesi, who was in constant correspondence with the owners.

Here Gaspare Spontini spent the last months of his life with his wife Celeste Erard, until his death on January 24, 1851. After that the building continued to host Celeste Erard's sojourns to Maiolati after she returned to live in France and became the headquarters of the Opere Pie.

Between 1920 and 1936 it was used as City Hall and then as an elementary school, treasury, pharmacy, public housing, cereal store and warehouse. It was not until 1951 on the occasion of the first centenary of his death that it was turned into a museum and, at the proposal of the Ministry of Education by Presidential Decree n. 1092 of June 19, 1951, it was declared a national monument.

Today the "Gaspare Spontini" Archive, Library, Museum (housed on three floors) is not only a place to display memorabilia, but also an important centre for study and research. The first floor preserves sheet music, music manuscripts, reproductions of autograph letters, stage photos of modern opera productions of his compositions and two 1820 fortepianos from the Erard Brothers, the family musical instrument company owned by Spontini's wife. The second floor, on the other hand, features a long corridor onto which the couple's domestic rooms open.